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Research Program 
ASAP Research Grants Currently Underway
Project Title: Prospective evaluation of cognitive function (brain fog) among individuals with or without syringomyelia before decompression surgery as compared to post surgery

Grant Recipient: Dr. Cammy Chicota, Spalding Rehabilitation Hospital, Aurora, Colorado


Project Title:
Investigation of the disease progression of pediatric patients with incidental Chiari I malformation

Grant Recipient: Kerri Thorn, PA-C, Children's National Medical Center, Washington, DC


Project Title:
The Genetics of Chiari Type I Malformation (CMI) with or without Syringomyelia

Grant Recipient: Dr. Allison Ashley-Koch, Center for Human Genetics, Duke University Medical School, Durham, North Carolina

Funding for this study is provided by the Marcy Speer Research Memorial Fund



Project Title:
Outcomes in Patients Undergoing Surgical Intervention for Chiari Type I Malformation with Syringomyelia

Grant Recipient: Bermans J. Iskandar, MD, University of Wisconsin at Madison, Tim M. George, MD, University of Texas at Austin

Funded in part by the Kids For A Cure Club
Completed Grants
Project Title: Importance of the Mechanical Forces in the Pathogenesis of Syringomyelia

Grant Recipient: Francis Loth, PhD, Department of Mechanical and Industrial Engineering, University of Illinois at Chicago

Read final report

Project Title: Investigation on the pathogenesis of post-traumatic syringomyelia (PTS): the roles of central canal occlusion and focal arachnoiditis on the contused and intact rat spinal cord

Grant Recipient: Christopher Shields, M.D., Professor and Chairman, University of Louisville School of Medicine, Louisville, KY  

Read final report

Project Title: Pre-Clinical Development of GABA cell therapy for chronic pain after SCI

Grant Recipient: Mary Eaton, PhD, University of Miami School of Medicine, Miami, FL
Project Title: Pre-Clinical Development of GABA Cell Therapy for Chronic Pain after Spinal Cord Injury

Grant Recipient: Mary Eaton, PhD, Miami Project to Cure Paralysis at the University of Miami School of Medicine

Project Title: Spatial and Temporal CSF Flow Patterns in Chiari I Malformation and the Development of Syringomyelia

Grant Recipient: Victor Haughton, MD and Bermans Iskandar, MD, University of Wisconsin Medical School
Project Title: Pre-clinical Development of GABA Cell Therapy For Chronic Pain After Spinal Cord Injury

Grant Recipient: Mary Eaton, PhD, Assistant Professor of Neurological Surgery, University of Miami

Project Title: Cytokines and Neuropathic Pain in Syringomyelia

Grant Recipient: Joshua Adler, MD, Associate Professor of Neurology, Wayne State University

Project Title: Importance of the Mechanical Forces in the Development of Syringomyelia for Patients With Chiari Malformation

Grant Recipient: Francis Loth, PhD, Assistant Professor, Department of Mechanical and Industrial Engineering, University of Illinois-Chicago

Project Title: Chiari I Malformation and Syringomyelia in Identical Twins Discordant
for Chronic Fatigue Syndrome


Grant Recipient: Dedra Buchwald, MD, Director, Chronic Fatigue Syndrome Cooperative Research Center, University of Washington

Project Title: Chiari Malformation I/Syringomyelia Genetic Research Study

Grant Recipient: Marcy C. Speer, PhD, Associate Research Professor, Department of Medicine, Center for Human Genetics, Duke University



Publications Resulting From ASAP Sponsored Research

Phenotypic definition of Chiari type I malformation coupled with high-density SNP genome screen shows significant evidence for linkage to regions on chromosomes 9 and 15.

Boyles AL, Enterline DS, Hammock PH, Siegel DG, Slifer SH, Mehltretter L, Gilbert JR, Hu-Lince D, Stephan D, Batzdorf U, Benzel E, Ellenbogen R, Green BA, Kula R, Menezes A, Mueller D, OrĂ³ JJ, Iskandar BJ, George TM, Milhorat TH, Speer MC.

Asymptomatic Chiari Type I malformations identified on magnetic resonance imaging.
Meadows J, Kraut M, Guarnieri M, Haroun RI, Carson BS

A genetic hypothesis for Chiari I malformation with or without syringomyelia.
Marcy C. Speer, Timothy M. George, David S. Enterline, Amy Franklin, Chantelle M. Wolpert, and Thomas H. Milhorat

Syringomyelia hydrodynamics: an in vitro study based on in vivo measurements.
Martin BA, Kalata W, Loth F, Royston TJ, Oshinski JN


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