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Research Program 

Research ASAP has Sponsored:

2007-2008 Awards
Project Title: Outcomes in Patients Undergoing Surgical Intervention for Chiari Type I Malformation with Syringomyelia

Grant Recipient: Bermans J. Iskandar, MD, University of Wisconsin at Madison, Tim M. George, MD, University of Texas at Austin
2005-2006 Awards
Project Title: Importance of the Mechanical Forces in the Pathogenesis of Syringomyelia

Grant Recipient: Francis Loth, PhD, Department of Mechanical and Industrial Engineering, University of Illinois at Chicago

Project Title: Investigation on the pathogenesis of post-traumatic syringomyelia (PTS): the roles of central canal occlusion and focal arachnoiditis on the contused and intact rat spinal cord

Grant Recipient: Christopher Shields, M.D., Professor and Chairman, University of Louisville School of Medicine, Louisville, KY

2004-2005 Awards
Project Title: Pre-Clinical Development of GABA cell therapy for chronic pain after SCI

Grant Recipient: Mary Eaton, PhD, University of Miami School of Medicine, Miami, FL
2003-2004 Awards
Project Title: Pre-Clinical Development of GABA Cell Therapy for Chronic Pain after Spinal Cord Injury

Grant Recipient: Mary Eaton, PhD, Miami Project to Cure Paralysis at the University of Miami School of Medicine

Project Title: Spatial and Temporal CSF Flow Patterns in Chiari I Malformation and the Development of Syringomyelia

Grant Recipient: Victor Haughton, MD and Bermans Iskandar, MD, University of Wisconsin Medical School
2002-2003 Awards
Project Title: Pre-clinical Development of GABA Cell Therapy For Chronic Pain After Spinal Cord Injury

Grant Recipient: Mary Eaton, PhD, Assistant Professor of Neurological Surgery, University of Miami

Project Title: Cytokines and Neuropathic Pain in Syringomyelia

Grant Recipient: Joshua Adler, MD, Associate Professor of Neurology, Wayne State University

Project Title: Importance of the Mechanical Forces in the Development of Syringomyelia for Patients With Chiari Malformation

Grant Recipient: Francis Loth, PhD, Assistant Professor, Department of Mechanical and Industrial Engineering, University of Illinois-Chicago

2000-2001 Awards
Project Title: Chiari I Malformation and Syringomyelia in Identical Twins Discordant
for Chronic Fatigue Syndrome


Grant Recipient: Dedra Buchwald, MD, Director, Chronic Fatigue Syndrome Cooperative Research Center, University of Washington
1998 Awards

Project Title: Chiari Malformation I/Syringomyelia Genetic Research Study

Grant Recipient: Marcy C. Speer, PhD, Associate Research Professor, Department of Medicine, Center for Human Genetics, Duke University



Publications Resulting From ASAP Sponsored Research

Phenotypic definition of Chiari type I malformation coupled with high-density SNP genome screen shows significant evidence for linkage to regions on chromosomes 9 and 15.

Boyles AL, Enterline DS, Hammock PH, Siegel DG, Slifer SH, Mehltretter L, Gilbert JR, Hu-Lince D, Stephan D, Batzdorf U, Benzel E, Ellenbogen R, Green BA, Kula R, Menezes A, Mueller D, Oro' JJ, Iskandar BJ, George TM, Milhorat TH, Speer MC.

Asymptomatic Chiari Type I malformations identified on magnetic resonance imaging.
Meadows J, Kraut M, Guarnieri M, Haroun RI, Carson BS

A genetic hypothesis for Chiari I malformation with or without syringomyelia.
Marcy C. Speer, Timothy M. George, David S. Enterline, Amy Franklin, Chantelle M. Wolpert, and Thomas H. Milhorat

Syringomyelia hydrodynamics: an in vitro study based on in vivo measurements.
Martin BA, Kalata W, Loth F, Royston TJ, Oshinski JN


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